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Science

Wikipedia pages on protein function prediction

I just received an email from Julian Gough , one of last year’s CAFA participants. He started a Wikipedia initiative on protein function prediction, which are barely stubs at the moment. EDIT: He alerted me to the fact that protein function prediction has virtually no presence on Wikipedia. So all you protein function predictors out there, please contribute. Yes, […]

The Search for Small finds Life on a Gradient

In Chapter 3 of The House at  Pooh Corner, Rabbit organizes a search for Small, “One of my friends and relations.”  Like a good manager (or scientist) Pooh lays out a program: As soon as Rabbit was out of sight, Pooh remembered that he had forgotten to ask who Small was, and whether he was the […]

Microbial Pancakes

  Prepared by daughter. Not to scale. Species not yet identified. Delicious.  

Gut microbes and diabetes

It seems that every day we are discovering more about the role of microbes to our health. We really have to revise our definition of what a human (or any other animal or plant) is: we are not just a creatures of 10,000,000,000,000 cells containing the DNA we got from mother and father. We have […]

Nobody knows you

With deepest apologies to the memory of Jimmy Cox. EDIT: I got a couple of concerned emails. No, this did not happen to me. Yet. Once I lived the life of a PI so rich, Research was going along without a hitch. Lab manager, four postdocs and grad students eight, My lab took up the […]

Open Cancer Research

  “We seek to download from the amazing successes of the computer industry two principles: that of open source, and that of crowdsourcing; to quickly, responsibly accelerate the delivery of targeted therapeutics to cancer patients. Our business model involves all of you. This research is funded by the public.”  

Circumcision, preventing fraud, and icky toilets. You know you’re going to read this.

In no particular order or ranking, recent and not-so-recent articles from PLoS-1. The common thread (if any): I thought they were pretty cool in one way or another.   1. Men don’t tell the truth about their penis. No kidding? But this is somewhat more serious. It has been accepted for some time that male […]

So what’s new with humans?

Man is the only animal that laughs and weeps, for he is the only animal that is struck with the difference between what things are and what they ought to be. — William Hazlitt We like to think that we are the only species capable of emotional self-awareness and therefore the only “animal that laughs […]

Oh, but to receive such a rejection letter!

It is with no inconsiderable degree of reluctance that I decline the offer of any Paper from you. I think, however, you will upon reconsideration of the subject be of opinion that I have no other alternative. The subjects you propose for a series of Mathematical and Metaphysical Essays are so very profound, that there […]

The genomics programming language

Genomics is a new and exciting programming language based on Brainfsck. Here are the commands: g Move pointer to the right. e Move pointer to the left. n Increment the cell at the pointer. o Decrement the cell at the pointer. m Jump forward past the matching i if the cell at the current pointer […]

Short bioinformatics hacks: reading mate-pairs from a fastq file

If you have a merged file of paired-end reads, here is a quick way to read them using Biopython: from Bio import SeqIO from itertools import izip_longest # Loop over pairs of reads readiter = SeqIO.parse(open(inpath), “fastq”) for rec1, rec2 in izip_longest(readiter, readiter): print rec1.id # do something with rec1 print rec2.id # do something […]

Rumors of The Scientist’s Demise Have Been Greatly Exaggerated

The Scientist is one of my favorite go-to destinations for keeping up with current biomedical research. That’s why I was rather sad when it was recently announced that The Scientist will be closing down. However, it seems like The Scientist will continue to be published after all:   NEW YORK, NY–(Marketwire – Oct 14, 2011) – […]

Not dead yet

  The Dead Body That Claims It Isn’t: I’m not dead. The Dead Collector: What? Large Man with Dead Body: Nothing. There’s your ninepence. The Dead Body That Claims It Isn’t: I’m not dead. The Dead Collector: ‘Ere, he says he’s not dead. Large Man with Dead Body: Yes he is. The Dead Body That […]

The Friedberg Lab is Recruiting Graduate Students

  The Friedberg Lab is recruiting graduate students, for both Master’s and Ph.D. WE ARE:  A dynamic young lab  interested in gene, gene cluster and genome evolution, understanding microbial communities and microbe-host interactions by metagenomic analyses, developing algorithms for understanding gene cluster evolution, and prediction of protein function from protein sequence and structure. YOU ARE: […]

Funny Science Friday: The IgNobels, Wall Street Journal

The IgNobel prizes were awarded this week. Yes, the Nobel prizes too, but the IgNobels are the really interesting ones. (For an thoughtful piece about why the Nobel Prizes in the sciences do not enhance or may even hurt scientific recognition, read Carl Zimmer’s piece at The Loom) . The IgNobel prizes are awarded annually for […]