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Science

Probably a good time to talk about pancreatic cancer

  Percent of pancreatic cancer patients diagnosed when the disease is still localized: 8 Their 5-year relative survival: 21.5% Percent of pancreatic cancer patients diagnosed when the disease has metastasized: 53 Their 5-year relative survival: 1.8% Mean survival rate after diagnosis: < 1 year Ranking in cause of cancer-related deaths worldwide: 4 Number of effective […]

Using phylogenetics to reconstruct a 59 million year old drug

Good news: Press Release 2011-10-03 The Nobel Assembly at Karolinska Institutet has today decided that The Nobel Prize in Physiology or Medicine 2011 shall be divided, with one half jointly to Bruce A. Beutler and Jules A. Hoffmann for their discoveries concerning the activation of innate immunity and the other half to Ralph M. Steinman […]

The power of science blogging

  Hats off to Jonathan Eisen for hosting this activity on his blog. (I’ll keep mine on, thank you. It’s raining cats and dogs here right now). A couple of weeks ago I posted a discussion about two papers that challenged the ortholog conjecture. Briefly, both papers stated that orthologs may not be such great […]

Microbial marketing

An original viral (or rather, fungal and bacterial) marketing campaign for the movie Contagion. Although the film tells the story of a fictional viral outbreak, the marketers of Warner Brothers Canada kept it in the realm of microbiology by teaming up with 25 microbiologists and creating what is probably the first agar-plated billboard, which they […]

Friday fun story: extreme bug hunting on MIRA

MIRA is a really cool sequence assembly software, developed and maintained by Bastien Chevreux. MIRA has a large and active community, led by the funny and gracious Bastien, for whom no problem is too small, or too large. Recently MIRA seemed to have developed a stochastic bug, one of those which are a serious headache […]

Postdoc positions available at Rutgers University

Postdoctoral Research Scientist Rutgers University Joint Appointment: Institute of Marine and Coastal Sciences, BioMaPS and Dept. of Biochemistry and Microbiology Two 2-3 year Postdoctoral Research Scientist positions are available. We are looking for young scholars with experience in the areas of computational biology. In the scope of this project, we will uncover how the metal-containing […]

Of Mice and Men or: Revisiting the Ortholog Conjecture

I  have posted quite a few times before about the acquisition of new functions by genes. In many cases a gene is duplicated, and one of the duplicates acquires a new function. This is one basic evolutionary mechanism of acquiring new functions. Sometimes, gene duplication occurs within a species: part of the chromosome may be […]

Short bioinformatics hacks: merging fastq files

So you received your mate-paired reads in two different files, and you need to merge them for your assembler. Here is a quick Python script to do that. You will need Biopython installed.   #!/usr/bin/env python from Bio import SeqIO import itertools import sys import os # Copyright(C) 2011 Iddo Friedberg # Released under Biopython […]

Can you chat with your reviewer?

The manuscripts I review invariably fall into four categories: 1. This is crap. (Rare). 2. This is terrific. (Even rarer). 3. This can be OK, but they really need to fix A, B & C. (fairly common). 4. If I only knew what they meant in point A, I could say whether they need to fix A, […]

Class X solar flare today

  Class X7 solar flare, viewed at 3:48am EDT today, August 9. A short guide to solar flares class types, from NASA. Class X is the biggest one, the kind that may disrupt communications. This one will mostly miss us, phew. The (hopefully minimal) magnetic storm is expected on Earth August 11.

Coconut headphones in science publishing

  After WWII, Pacific islands occupied by the US military were regularly receiving goods via air. Once the military evacuated , the goods stopped arriving. Some inhabitants of those islands mistakenly thought that receiving the cargo was due to some divine intervention that required rituals they saw American servicemen performing. This eventually led them to […]

Tweets from AFP/CAFA 2011

The AFP/CAFA 2011 meeting was held on July 15 and July 16. Yes, it was a huge success, and I’m not just saying that beacuse I am one of the organizers.  I will write up something more comprehensive soon; in the meantime, here are my tweets from the meeting. I am learning a lot about […]

ISMB 2011 tweets

ISMB this year had quite a few twiterrers. Hashtag: #ISMB. I tried to collect all the #ISMB tweets, so I wrote my own twitter scavenger script, but it seems to go only 3 days back.  I am not sure if this is a Twitter feature, or something with the library I am using (tweepy) or […]

Guest Post: Thoughts on the Superjournal

Guest post by Leighton Pritchard The new top-tier competitor to Science and Nature proposed by three leading funders of scientific research last week is a great idea, but I think runs a risk of opening the scientific process to a potentially damaging slander by opponents of science. As practising academic scientists we’re all concerned, and […]

Music Monday Double Feature: They are Climate Scientists

Australian climate scientists lip-syncing “I’m a Climate Scientist” from Hungry Beast. (Warning: profane language.)