TL;DR: NIH are scaling back funding on model organism databases, which will degrade annotation quality. This can have far-reaching implications in many aspects of biology and computational biology. There’s a letter you can sign electronically, please do. <http://www.genetics-gsa.org/MODsupport> I am hoping to write a more detailed post on why this is important, but for the […]
Starting June 1, 2015, my lab is moving to Iowa State University in Ames, Iowa, and I’m very excited about this. I’ll be joining a growing cohort of researchers as part of a presidential “big data” hire the university has started a year ago. The research environment is superb, and there are some great bioinformaticians and genomics […]
A question to genome annotators out there. I need a simple genome annotator for annotating bacteriophage genomes in an undergraduate course. Until now, we used DNAMaster but for various reasons I would like to move away from that. Here’s what I need for class: 1. Annotate a single assembled linear chromosome, about 50,000 bp, 80-120 genes, no […]
TL; DR: The genome sequence of the North American Wood Frog will tell us a lot about the genetic control of freezing and reanimating whole organisms. My friend and colleague, Dr. Andor Kiss is crowdfunding this project. If you would like to help, please go to experiment.com. You will get acknowledged by name in the paper. To […]
What makes a nerd a nerd? The stereotype is that of someone with a high intelligence, coupled with social awkwardness and a wardrobe that may alert the fashion police. Now scientists think they may found the genomic links to these traits. There was always a strong suspicion of a genetic component in people that are […]
Announcing CAFA 2: The Second Critical Assessment of protein Function Annotations Friends and Colleagues, We are pleased to announce the Second Critical Assessment of protein Function Annotation (CAFA) challenge. In CAFA 2, we would like to evaluate the performance of protein function prediction tools/methods (in old and new scenarios) and also expand the challenge to […]
The state of biology today: Our main problem is turning these DNA data into useful information. Finding genes and other functional genomic element, characterizing them, understanding their function and their impact on Life – all these are challenges that will remain with us for a long time, and which have revolutionized biology into the […]
A new paper from my lab and Patsy Babbitt’s lab in UCSF has recently been published in PLoS Computational Biology. It is something of a cautionary tale for quantitative biologists, especially bioinformaticians and system biologists. Genomics has ushered biology into the data rich sciences. Bioinformatics, developing alongside genomics, provided the tools necessary to decipher genomic […]
From the organizers of CAGI 2013. I have been to the Critical Assessment in 2010 and 2011, and even participated as an assessor. It’s a fun meeting, and if your work involves prediction of phenotypes from genotypes, there is still time (just about) to accept some of the challenges. The Critical Assessment of Genome Interpretation […]
Back to ancient life, what exactly defines life, and where does life end and non-life begin. One of my favorite subjects, and one of which I am the least knowledgeable. Doesn’t stop me writing about it though. Viruses are… well… not really life. Or so says common wisdom. They have some elements of life: a […]
Our lab has a new project and website up. The project is BioDIG: Biological Database of Images and Genomes. BioDIG lets you combine image data and genome data of, well, just about anything which you can make images and have a genome, or partial genomic information. You can upload your image, annotate (tag) parts of […]