Displaying posts categorized under

Genomics

Personalized Medicine Poetry

The personal genomics company 23&me is hosting a poetry contest. The winner receives a free pass to the Personalized World Medicine Conference. Poems should include a bunch of keywords having to do with 23&me, personalized genomics and all that jazz. I’m no poet (and don’t you know it), so here is my Haiku non-entry: My genome was seq- […]

Making genomes less CAGI

cag·ey    /ˈkājē/ (adjective) Reluctant to give information owing to caution or suspicion CAGI /ˈkājē/ (acronym) Critical Assessment of Genomic Interpretations. For details keep reading. The ability to sequence one’s genome adds a new dimension to the ancient maxim “know thyself”. What could be more revealing of one’s self than one’s own blueprint, explaining existing […]

Carnival of Evolution #29

Yes, it’s that time when we all get together in front of the screen to watch another beautiful game played by that fantastic team contributing to the Carnival of Evolution. This time hosted on the lovely green pitch of Byte Size Biology. So get your popcorn, sunflower-seeds, crisps or any other culturally-appropriate sports-watching food and…… […]

Now that’s a f***ing big genome!

It isn’t junk DNA: God just commented out a lot of crappy code as he rolled out releases. — An old bioinformaticians’ joke (Hey, I never said it was a funny joke…) Why are some genomes so big? I mean, seriously. Why would the marbled lungfish with a genome weighing 132.83 picograms (pg) need an […]

Lake Arrowhead Microbial Genomics Conference

Quick post: at the Lake Arrowhead Microbial Genomics Conference. I’m a bad microblogger, but thankfully Jonathan Eisen and Ruchira Datta are doing a great job of covering this conference live. There is a friendfeed room. The Twitter hashtag is #LAMG10.  The science, people, food and location are all great. My student, David Ream, is presenting […]

Protein Function: how do we know that we know what we know?

The trouble with genomic sequencing, is that it is too cheap. Anyone that has a bit of extra cash laying around, you can scrape the bugs off your windshield, sequence them, and write a paper. Seriously? Yes, seriously now: as we sequence more and more genomes, our annotation tools cannot keep up with them. It’s […]

Celebromics? HeavyMetalomics? Advertomics? Anniversomics!

René Goscinny would probably have done a better job of naming the new trend of personal genomics (genomix?) companies to sequence celebrities genomes. Heck, we might have even done Obelix’s  and Asterix’s genomes to find out  if Obelix can drink the magic potion without Getafix’s (Panoramix’s) admonishments that it might do him harm, or to […]

Computational Bridge to Experiments

A bit of background information: this is a meeting I am really happy to be part of, and even more so honored to be a co-organizer. One of my main scientific interests is the prediction of the function of genes and proteins of unknown function. Some background information: we have sequenced more than 1000 genomes […]

Closing gaps

Geek alert: this post for coders. So you sequenced your genome, reached an optimally small number of contigs, they look sane, and now you would like to see what you need for the finishing stage. Namely, how many gaps you have and what are their sizes. UPDATE: “might just be worth clarifying this is for […]

There is a little bit of Neanderthal in many of us

Big party at Science journal today, with the publication of a comprehensive draft Neanderthal genome. (Free access, nice going Science). Actually, it is a partially assembled draft of 60% of the total genome, but 60% of the genome from a human that was last seen on Earth 28,000 years ago is quite an achievement. The […]

Well, color me surprised

Nature is colorful. And the family of pigments that is mostly responsible for these colors are carotenoids. Carotenoids  make the apples and tomatoes red, the lemons and grapefruit yellow, the pumpkins oranges and, yes carrots, (from which their name is derived), orange. Carotenoids also make flamingos and salmon pink, and color the puffin’s bill orange. […]

New poll: would you make your genome public?

Would you have your genome sequenced for free?  Conditions: you must license it for all use; a liberal CC-no attribution-like license which allows for commercial use as well. Also, your genome will be made public with many personal data  such as age, height, sex, weight, ethnicity, personal status (we want to find the “money making […]

Obesity: the role of the immune system

Obesity is one symptom of several, which together constitute what is now termed metabolic syndrome. Morbid obesity is also associated with a host of other symptoms including high blood sugar, high blood lipids, insulin resistance  and liver disorders. The root causes of which are traced back to excessive food consumption, reduced physical activity and in […]

I never metagenomics I didn’t like

“Let another man praise thee, and not thine own mouth; a stranger, and not thine own lips.” — Proverbs 27:2 “What-ever” —  Me In PLoS Computational Biology this week, a trio of researchers provides a review of the challenges that metagenomics might ― and already do ― pose for bioinformaticians. The authors refer to metagenomic […]

A sh*tload of data

There are more microbial cells in our body than our own. Those microbes are not just passive hitchhikers or conversely, malicious agents of disease. They affect our well-being and health in a much broader spectrum than simply “bad” or “passive”. Among other things our gut microbes play an important role in digestion, have been linked […]