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Biology

Microbial Art

  We have some really talented students in our department. And I don’t just mean the science. I am honored to present the colorful and hilarious microbial artwork of Amber Beckett. Created between gel runs at Natosha Finley’s lab:      

Life is short

Continuing with rather philosophical musings about life, Ed Trifonov has recently suggested a new approach to defining life:  let’s just vote on the definition. So how does that work? And why should it work in the first place? Note that I am diving straight into the subject, and not prefacing this post with a review […]

Wikipedia pages on protein function prediction

I just received an email from Julian Gough , one of last year’s CAFA participants. He started a Wikipedia initiative on protein function prediction, which are barely stubs at the moment. EDIT: He alerted me to the fact that protein function prediction has virtually no presence on Wikipedia. So all you protein function predictors out there, please contribute. Yes, […]

The Search for Small finds Life on a Gradient

In Chapter 3 of The House at  Pooh Corner, Rabbit organizes a search for Small, “One of my friends and relations.”  Like a good manager (or scientist) Pooh lays out a program: As soon as Rabbit was out of sight, Pooh remembered that he had forgotten to ask who Small was, and whether he was the […]

Microbial Pancakes

  Prepared by daughter. Not to scale. Species not yet identified. Delicious.  

Gut microbes and diabetes

It seems that every day we are discovering more about the role of microbes to our health. We really have to revise our definition of what a human (or any other animal or plant) is: we are not just a creatures of 10,000,000,000,000 cells containing the DNA we got from mother and father. We have […]

Circumcision, preventing fraud, and icky toilets. You know you’re going to read this.

In no particular order or ranking, recent and not-so-recent articles from PLoS-1. The common thread (if any): I thought they were pretty cool in one way or another.   1. Men don’t tell the truth about their penis. No kidding? But this is somewhat more serious. It has been accepted for some time that male […]

So what’s new with humans?

Man is the only animal that laughs and weeps, for he is the only animal that is struck with the difference between what things are and what they ought to be. — William Hazlitt We like to think that we are the only species capable of emotional self-awareness and therefore the only “animal that laughs […]

The genomics programming language

Genomics is a new and exciting programming language based on Brainfsck. Here are the commands: g Move pointer to the right. e Move pointer to the left. n Increment the cell at the pointer. o Decrement the cell at the pointer. m Jump forward past the matching i if the cell at the current pointer […]

Short bioinformatics hacks: reading mate-pairs from a fastq file

If you have a merged file of paired-end reads, here is a quick way to read them using Biopython: from Bio import SeqIO from itertools import izip_longest # Loop over pairs of reads readiter = SeqIO.parse(open(inpath), “fastq”) for rec1, rec2 in izip_longest(readiter, readiter): print rec1.id # do something with rec1 print rec2.id # do something […]

Not dead yet

  The Dead Body That Claims It Isn’t: I’m not dead. The Dead Collector: What? Large Man with Dead Body: Nothing. There’s your ninepence. The Dead Body That Claims It Isn’t: I’m not dead. The Dead Collector: ‘Ere, he says he’s not dead. Large Man with Dead Body: Yes he is. The Dead Body That […]

The Friedberg Lab is Recruiting Graduate Students

  The Friedberg Lab is recruiting graduate students, for both Master’s and Ph.D. WE ARE:  A dynamic young lab  interested in gene, gene cluster and genome evolution, understanding microbial communities and microbe-host interactions by metagenomic analyses, developing algorithms for understanding gene cluster evolution, and prediction of protein function from protein sequence and structure. YOU ARE: […]

Funny Science Friday: The IgNobels, Wall Street Journal

The IgNobel prizes were awarded this week. Yes, the Nobel prizes too, but the IgNobels are the really interesting ones. (For an thoughtful piece about why the Nobel Prizes in the sciences do not enhance or may even hurt scientific recognition, read Carl Zimmer’s piece at The Loom) . The IgNobel prizes are awarded annually for […]

Using phylogenetics to reconstruct a 59 million year old drug

Good news: Press Release 2011-10-03 The Nobel Assembly at Karolinska Institutet has today decided that The Nobel Prize in Physiology or Medicine 2011 shall be divided, with one half jointly to Bruce A. Beutler and Jules A. Hoffmann for their discoveries concerning the activation of innate immunity and the other half to Ralph M. Steinman […]

The power of science blogging

  Hats off to Jonathan Eisen for hosting this activity on his blog. (I’ll keep mine on, thank you. It’s raining cats and dogs here right now). A couple of weeks ago I posted a discussion about two papers that challenged the ortholog conjecture. Briefly, both papers stated that orthologs may not be such great […]