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Microbiology

Computational Bridge to Experiments

A bit of background information: this is a meeting I am really happy to be part of, and even more so honored to be a co-organizer. One of my main scientific interests is the prediction of the function of genes and proteins of unknown function. Some background information: we have sequenced more than 1000 genomes […]

A cure for Ebola?

There are few infectious diseases as violent and as lethal as the Ebola Haemorragic Fever.  This terrible disease was first described in 1976 at a mission hospital at the Ebola river in Zaire (now the Democratic Republic of Congo).  The disease is 80% fatal, the victims die painfully from a literal meltdown of their organs. […]

A non-post about Craig Venter’s new bug

In case you have been vacationing in a parallel universe in the past two days, you should have heard about the new synthetic bacterium created at the J Craig Venter Institute. In a nutshell, the scientific team synthesized an artificial chromosome of the bacterium Mycoplasma mycoides and transferred it to another bacterium, Mycoplasma capricolum. The […]

I never metagenomics I didn’t like

“Let another man praise thee, and not thine own mouth; a stranger, and not thine own lips.” — Proverbs 27:2 “What-ever” —  Me In PLoS Computational Biology this week, a trio of researchers provides a review of the challenges that metagenomics might ― and already do ― pose for bioinformaticians. The authors refer to metagenomic […]

WoW is full of bacteria

Speaking of sampling bacteria, this ties in well with the previous post about GEBA. And by “well” I mean “in an alternate-universe/ altered-consciousness manner”. The voices in the song are sampled from this KFC employee training tape. The video won a prize in machinima.com. So if you like World of Warcraft, bacteria, KFC, sampled music, […]

Filling in the evolutionary blanks, genome by genome

After hearing Jonathan Eisen and Nikos Kyripdes talk about GEBA in various meetings, it is great to see the paper finally come out, and under a CC license too. Good move for everyone. GEBA is the Genomic Encyclopedia of Bacteria and Archaea. The idea is simple: we have >1000 prokaryotic genomes in GenBank as of […]

Photosynthesis, phages and structures: there’s treasure everywhere!

Here’s a really cool work, published this September in Nature.. Why did I choose this work?  Well, it’s a major discovery, and it’s all done using bioinformatics, and fairly simple bioinformatics at that. The power of metagenomics and bioinfromatics: in a mass of data you just have to know what you are looking for, and […]

Blog Action Day: the Methane Pulse

Blog Action Day focuses this year on climate change, which, like everything else on this planet, is also a microbial matter. Howzat? Methane (CH4) is a greenhouse gas which has heat retention capability 23 times of that of CO2.  Soil methanogens are the chief global producers of methane. There are an estimated 7.5x 109 tons […]

The medium-rare biosphere

All the roots hang down Swing from town to town They are marching around Down under your boots All the trucks unload Beyond the gopher holes There’s a world going on Underground — Tom Waits, “Underground” Our picture of the microbial biosphere is heavily skewed towards what we can see, culture, and are interested in. […]

The Craigslist of Antibiotic Resistance

(Before we get going: this the the 100th post on Byte Size Biology. Happy Birthday to me!) Resistance to antibiotics is a huge clinical problem. In the US, more people die of  methicillin-resistant Staphylococcus aureus (MRSA) infections (nearly 19,000 in 2006) than of AIDS (14,627).  We know that antibiotic resistance is carried on mobile genetic […]

Freeloading pays off, but only up to a point.

Quorum sensing Social behavior is not exactly the first term that comes to mind with relation to microbes. After all, we assume a certain amount of intelligence and an ability to implement a behavioral pattern in response to peer actions. Humans, yes. Apes, yes. Birds of a feather flock together… so birds, yes. Ants and […]

PLoS Currents: Influenza. Because knowledge should travel faster than epidemics

(Full disclosure before I start: I am an academic editor in PLoS ONE. I have no financial stake in PLoS, and as far as I know, they have none in me. They’d better not, if they know what’s good for them). PLoS have come up with yet another cool mechanism for scientific communication: PLoS Currents. […]

Coast to coast (almost) pt. 3: big country, small things

We are “going up” the Grand Staircase in Utah now.  After Zion, we hiked in Bryce Canyon, and tomorrow we will explore the area around Escalante and Capitol Reef. While constantly bombarded by the grand geological marvels of these places, it’s probably important to keep track of some small things. Like this leaf -mimicking grasshopper […]

Absolut standards: report from the M3-2009 meeting, part 2: signature genes and big science

Some more presentations from the metagenomics, metadata, and metaanalysis (M3) meeting, Stockholm June 27, 2009 Pathway Signature Genes Lucas A. Brouwers, Martijn A. Huynen and Bas E. Dutilh CMBI / NCMLS, Radboud University Nijmegen Medical Centre, The Netherlands If we take a sample of soil, how can we know whether it is adequate for growing […]