Hats off to Jonathan Eisen for hosting this activity on his blog. (I’ll keep mine on, thank you. It’s raining cats and dogs here right now).

A couple of weeks ago I posted a discussion about two papers that challenged the ortholog conjecture. Briefly, both papers stated that orthologs may not be such great predictors for molecular function. One study from  Indiana University by  has shown that paralogs may be better predictors than orthologs for molecular function. Or, at the very least, paralogs should not be excluded as predictors. This paper has generated quite a bit of interest and controversy. Consequently, Eisen has invited Matthew Hahn, the lead author to write about “the story behind the story” in Eisen’s well-read blog. The post is a great read, and has generated an animated discussion in the comments area. You do need to clear quite a bit of time to go through both Hahn’s guest post and the comment thread: the topic is a rather complex one, and as explained in the comments thread, one problem is that the ‘ortholog conjecture’ itself seems to be not well-defined.

I kept checking in to Eisen’s blog to read the elongating comment thread. It seems that now a special session on the topic may be in the works for the 2012 annual meeting of the Society for Molecular Biology and Evolution following this discussion. So great to see such an involved community getting together.

I am learning a lot about scavenging tweets.  Apparently, I cannot go back beyond a few days using the api.search() function. Hence, if I try to search for all the #AFPCAFA11 hashtags I will get nothing from the meeting’s dates. But if I look for a user’s tweets using api.user_timeline() I can go back for months on the users timeline, and then filter out the tweets with the relevant hashtags.  Since it seems I was the principal twiterrer in that meeting, I’m putting up my tweets here. Apologies to the others who recorded the meeting using Twitter: if you want your tweets included, drop me a line with your Twitter user name.

Thu Jul 14 16:04:22 2011 At Vienna. #ISMB #AFPCAFA11 #ISMB11
Thu Jul 14 16:07:34 2011 At Vienna #ISMB #AFPCAFA11 Curious who is the best protein function predictor? Join us. http://bit.ly/htv3J7
Fri Jul 15 09:10:24 2011 Jesse Gillis from UBC on a function prediciton post-mortem #AFPCAFA11 #ISMB
Fri Jul 15 09:12:11 2011 This is going to be fun. Jesse Gillis UBC. Postmortem on MouseFunc #ISMB #AFPCAFA11 Precision / Recall of 0.06… argh.
Fri Jul 15 09:14:14 2011 http://bit.ly/obSISi MouseFunc experiment #AFPCAFA11 #ISMB
Fri Jul 15 09:28:58 2011 Multifunctionality affect prediction profoundly. Take-home message from Jesse Gillis’ talk #AFPCAFA11 #ISMB
Fri Jul 15 09:31:22 2011 Next up: Meghana Chitale from @kiharalab #ISMB #AFPCAFA11
Fri Jul 15 09:36:44 2011 Co-occurrence association scores. CAS Lookiong for associations across GOs: between a BPO term and a CCO term, for example. #AFPCAFA11
Fri Jul 15 09:41:17 2011 Missing enzyme predictions. My fav. Chtiale at #ISMB #AFPCAFA11
Fri Jul 15 09:56:08 2011 Yanay Ofran from Bar ilan U about multifunctionality. How to assess the number of false positives? #ISMB #AFPCAFA11
Fri Jul 15 09:56:44 2011 Prediciton of photosynthesis in an elephant genome is a good sign of false positives. Yanay #ISMB #AFPCAFA11
Fri Jul 15 10:02:56 2011 Precision of short motifs is surprisingly high. Yanay, #ISMB #AFPCAFA11
Fri Jul 15 10:05:42 2011 short motifs identify functional motifs. Whereas homology identifies evolutionary relatedness. #AFPCAFA11 #ISMB
Fri Jul 15 10:09:14 2011 Next up: me. #AFPCAFA11 #ISMB
Fri Jul 15 11:44:45 2011 David Jones from UCL is talking about his #AFPCAFA11 predictions. Many different features. #ISMB
Fri Jul 15 11:47:18 2011 profile-profile fold recognition works well in Function prediction as well. #AFPCAFA11 #ISMB
Fri Jul 15 11:53:02 2011 Jones talking about why it is unhealthy to exercise in the morning. #AFPCAFA11 #ISMB generation of free radicals. #excusesaregreat
Fri Jul 15 11:56:43 2011 49,000 features in an SVM. #ISMB #AFPCAFA11
Fri Jul 15 11:57:47 2011 Hard to believe no redundancy in 49K features…. #ISMB #AFPCAFA11
Fri Jul 15 11:59:17 2011 “I like this plot and I would make a t-shirt out of it, but in terms of scientific value its worth is zero”. Jones, #AFPCAFA11 #ISMB
Fri Jul 15 12:01:09 2011 New term heard for a 2nd time at #ISMB #AFPCAFA11 “postdiction” as opposed to “prediction”. #notsurewhatitmeans
Fri Jul 15 12:16:49 2011 Lightning talks at #AFPCAFA11 #ISMB starting now
Fri Jul 15 12:35:51 2011 Mary Jo Ondrechen on SALSA at #AFPCAFA11 #ISMB structure –> function.
Fri Jul 15 12:36:45 2011 CDEHKRY make up 75% of all catalytic sites. Mary Jo #ISMB #AFPCAFA11
Fri Jul 15 12:50:50 2011 Jeffrey Yunes from UC Berkeley on SIFTER from Steven Brenner’s lab. #AFPCAFA11 #ISMB
Fri Jul 15 14:28:20 2011 Patrik Koskinen on a function prediction method called PANNZER. This will roll over well. #ISMB #AFPCAFA11
Fri Jul 15 14:30:30 2011 More information on PANNZER and the other methods at #AFPCAFA11 here: http://bit.ly/l9ayW9 #ISMB11
Fri Jul 15 14:33:16 2011 Koskinen mentioning Biothesaurus http://bit.ly/rnHdzp which removes errors due to synonyms #AFPCAFA11 #ISMB
Fri Jul 15 14:43:09 2011 Question: “How do you pronounce the name of that volcano that erupted in Iceland?” Answer: “I don’t”. Koskinen #AFPCAFA11 #ISMB
Fri Jul 15 14:50:27 2011 Olivier Lichtarge on using Evolutionary Trace Annotation (ETA) for function prediction. #AFPCAFA11 #ISMB
Fri Jul 15 14:51:12 2011 A network of protein structure networks. Memories of fragnostic. #AFPCAFA11 #ISMB
Fri Jul 15 14:52:49 2011 Using network diffusion to annotate protein structures. Lichtargee. #AFPCAFA11 #ISMB
Fri Jul 15 14:57:19 2011 compressing a clique to a star graph by adding a pseudo-node. Reduces problem from O(n^2) to O(n). Lichtarge #ISMB #AFPCAFA11
Fri Jul 15 15:09:17 2011 Amos Bairoch: of prosite, swissprot and expasy fame #AFPCAFA11 #ISMB
Fri Jul 15 15:12:51 2011 Due to alt-splicing and PTM 20,000 human genes –> 5M different molecules! Bairoch #AFPCAFA11 #ISMB
Fri Jul 15 15:15:50 2011 Status codes of human protein function annotations: Maybe, potentially, putative, expected and hopefullly. Bairoch #ISMB #AFPCAFA11
Fri Jul 15 15:17:10 2011 >100 GPCRs for which we do not know the ligand. Bairoch #ISMB #AFPCAFA11
Fri Jul 15 15:19:13 2011 Bairoch now talking about CALIPHO. 1)experimental verification of human protein function; 2)enable bioinformatics for same. #ISMB #AFPCAFA11
Fri Jul 15 15:20:44 2011 “How many ppl in this room have never used swissprot”. 0. #AFPCAFA11 #ISMB
Fri Jul 15 15:23:24 2011 Bairoch looks at small <100aa intracellular protiens in experimental assays. #AFPCAFA11 #ISMB
Fri Jul 15 15:26:26 2011 Interesting proteins are expressed in olfactory pits of zebrafish. I didn’t know fish smell. #AFPCAFA11 #ISMB
Fri Jul 15 15:33:09 2011 If you get a new function, you cannot predict it, because of no ontology (yet). #AFPCAFA11 #ISMB
Sat Jul 16 06:58:43 2011 Predrag Radivojac explaining the vagaries of GO annotated databases #AFPCAFA11 #ISMB
Sat Jul 16 06:59:48 2011 Assessment of protein function prediction methods going on now in Hall L #ISMB #AFPCAFA11
Sat Jul 16 07:04:08 2011 Radivojac: “It’s possible to achieve a precision of 1, it just won’t happen”. #AFPCAFA11 #ISMB
Sat Jul 16 07:29:50 2011 Assessment of protein function prediction methods going on now in Hall L #ISMB #AFPCAFA11 http://bit.ly/htv3J7 Sean Mooney is up.
Sat Jul 16 08:05:49 2011 Christine Orengo on her team’s work at #AFPCAFA11
Sat Jul 16 08:06:28 2011 Orengo says that they are not really function predictors, but evolutionary classifiers #AFPCAFA11 #ISMB
Sat Jul 16 09:18:03 2011 Shaneka Simmon from Jackson State on predicting functions associated with biofeuls – universal stress protein domains. #AFPCAFA11 #ISMB
Sat Jul 16 09:21:30 2011 Simmons: look for diversity of universal stress response genes. in Rhodopseudomonas palustris. #AFPCAFA11 #ISMB11
Sat Jul 16 11:33:52 2011 http://yfrog.com/kevdmbqj #AFPCAFA11 #ismb discussion panel now
Sat Jul 16 14:46:07 2011 Wyatt shows that paralogs actually give better annotation transfer than orthologs. http://bit.ly/nWShuB #AFPCAFA11 #ISMB
Sat Jul 16 14:47:17 2011 Wyatt’s claim runs contrary to common wisdom. Which is good http://bit.ly/nWShuB #AFPCAFA11 #ISMB
Thu Jul 21 22:42:34 2011 After all the talk about standards at #AFPCAFA11 #ISMB this is very timely: http://xkcd.com/927/

3quarksdaily are running their annual competition for best science blog entry. There are 87 really great blog posts competing there for the votes of  3QD readers. But who has the time to read through all of them? So let me make it easy for you: vote for me.

This blog’s “Dead Salmon” blog post has been nominated. To get the prize, I need your help. Only the top 20 entries out of 87 nominees will be considered for the final prizes. Please vote for Byte Size Biology: but did you check your results using a dead salmon? If you vote for me, you don’t waste time going through all the other posts, you know you voted for a great post (read it, it’s totally cool. Seriously). And you get to do you civic duty. Or something.

So vote. Then have your family members vote. Your work mates. Your lovers. Your pets. Your car mechanic, your dentist, your hairdresser, your haberdasher, your dog walker, your parole officer, your tattoo artist, your chauffeur and your bartender. Spread the word. Retweet, and share!

There are some interesting developments regarding the February outbreak of Legionelliosis which was traced to the Playboy mansion. Reminder: over 120 delegates of the DOMAINFest in Santa Monica, California came down with symptoms of a respiratory illness. The convention included a trip to the Playboy mansion, which later was suspected as the outbreak source. The convention was held Feb 1-4, 2011. The first inquiry to the  LA County Department of Health (LAC DPH) of a suspected legionellesis outbreak was made by the media on February 11. When tracing the outbreak, LAC DPH and CDC scientists discovered a trail of reports preceding February 11 in social media,  including Facebook and Twitter. The Wikipedia entry was updated almost at the same time when the LAC DPH inquiry was made.

Source: LA Times. From a presentation by Dr. Caitlin Reed

Note that there is quite a bit of information in this entry already!

The scientists identified several risk factors: staying at either one of the hotels, and two parties. They assessed the exposure risk based on the fraction of people who were in those venues and who became sick. To do so, they circulated questionnaires, via email and a Facebook list. They came up with this:

Source: LA Times. From a presentation by Dr. Caitlin Reed

The February 3 “Venue A” party seemed to hold the largest relative risk (RR), by far.  That was the Playboy mansion. Indeed, checking the water at the grotto where the party was held:

Source: LA Times. From a presentation by Dr. Caitlin Reed

The scientists concluded that use of social media to trace outbreaks has its pros and cons. The biggest pro was the ability to contact all conference attendees quickly, even though they are geographically dispersed. Also, the Facebook list, tweets and email encouraged a fast response to the survey. They did have some red herrings, and had to put effort into rumor control. I am not sure how much the last two were amplified by the social media effect.

The full slide presentation, and more information are at the Los Angeles Times.

Why yes, one of my posts did make it in. However did you guess?

Credit: xkcd.com

But now the science in the article itself is coming under fire. Several blog posts by notable microbiologists and biochemists  have questioned the claims made in the paper. To sum those up: yes, the microbes contain arsenate, the can grow on arsenic-rich media but there is no convincing evidence that arsenic gets incorporated into DNA, much less other molecules that use phosphate. Because this research is so much in the spotlight, the comments on it are in the spotlight too. I believe we will see some very interesting correspondence on the website and in the upcoming issues of Science.

Which brings me to the point of this post: is the peer-review publication culture undergoing a reform?  The arsenate bacteria article itself went through the peer-review mill, which means that at least three scientists which are credited as experts in the field have looked at it and given it a clean bill of health. But once it got published, hundreds of microbiologists and biochemists had a look, and many were less than convinced of some of its claims.  So which is better for the process of peer-review: three anonymous referees before publication, or 100 after? Or maybe we should use both?

A personal example: I recently  published a paper  in PLoS Computational Biology, which went through two pre-publication review cycles making it much better. However, even after those revisions an error (minor, fortunately) slipped through. A reader emailed me about it, and I immediately went to PLoS-CB‘s site and addressed that error as an inline comment in the paper. This mechanism provided by PLoS is laudable: I wish it were used more, and that other journals could provide it.

So, post-publication peer-review seems to be a good thing: it quickly identifies issues with the science, and helps to fix them.  So why is it not done more? Well, for one, there is the lack of anonymity. Post-publication commentators do not have the luxury of the official peer-reviewers of hiding their identity. Another is lack of credit: while some credit is given for pre-publication review, which is recognized as service rendered to the community, none is given yet for post-publication review. But why not? It is scientists like Rosie Redfield, Larry Moran, Jim Hu and others who did a great public service by taking the time to carefully read and then publicly critique the paper.  And in case there are still doubters of the value of science blogging, please read this piece by Larry Moran and for blogging as a career enhancer in science, “10 benefits for my career of blogging/ tweeting etc.) #fb” by Jonathan Eisen.

Where am I going with this? I’m not sure. But it seems like the fallout from the arsenate bacteria paper brings to light a new kind of science culture, in which post-publication critiques in expert science blogs are given. Perhaps all this energy could be harnessed to provide a better publication environment for research papers.  This has been going on for some time, as many science bloggers emphasize paper critique. But high profile incidents like the arsenate bacteria bring the value of post-publication review to light. To paraphrase a quote by Carl Sagan which was mentioned at the press conference held when the paper was published: “extraordinary claims attract extraordinary blogging”.

Wolfe-Simon F, Blum JS, Kulp TR, Gordon GW, Hoeft SE, Pett-Ridge J, Stolz JF, Webb SM, Weber PK, Davies PC, Anbar AD, & Oremland RS (2010). A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus. Science (New York, N.Y.) PMID: 21127214

Yes, it’s that time when we all get together in front of the screen to watch another beautiful game played by that fantastic team contributing to the Carnival of Evolution. This time hosted on the lovely green pitch of Byte Size Biology. So get your popcorn, sunflower-seeds, crisps or any other culturally-appropriate sports-watching food and…… the referee whistles! The game has begun!

Phenotypes! How do they happen?

Kicking off is Grrlsicentist from Punctuated Equilibrium telling us How the Penguin got its Tuxedo. While skillfully dribbling across the field, she tells the story of fossilized feathers from a giant, extinct penguin which contain fossilized melanosomes: intracellular structures whose shape can that tell us of the feather coloration of the bird. No, it was not black and white, but rather brownish and gray. However, melanosomes also strengthen the feathers, and today’s giant melanosomes, giving the familiar black coloration may have evolved as a results of a selection for feather strength, rather than color. Feather-minded (but far from feather brained!) she touches the ball across the defender and reports on how the parrot got its beautiful plumage. (Norwegian Blue?) Would you have thought resistance to bacteria degradation?! A short pass to Jerry A. Coyne who, while on the same topic, explains in Why Evolution is True about the evolution of cat coat-patterns and other issues relating to genetics of the coat in cats.  He makes a quick pass to Bjørn Østman who may have personally discovered the next stage* in feline evolution: the six digit cat! Bjørn toe-punches the ball hard and…

…the ball travels high forward left  to be intercepted by Eric Michael Johnson from The Primate Diaries in Exile. He high-knees the ball twice while asking whether our ancestors were polygamists, monogamists, or happy sluts? All this in his post: “Sex Evolution and the Case of the Missing Polygamists“. Eric launches it off with a strong left kick, the ball arches and jumps once on the ground, only to encounter  Jason Goldman’s knee, bouncing the ball while showing a movie which presents two different hypotheses explaining how wolves were domesticated into dogs. The first: young wolves would be adopted into the camps of early humans. Only those who were most tame would breed with eachother, and over many generations, the domestic dog would emerge. The second: wolves “chose” to be domesticated – they noticed a lot of tasty trash around human encampments, and if they were unafraid enough to hang around, they got to eat lots of leftovers, and those individuals would mate, and over generations, the domestic dog would emerge. His theory-and-ball juggling are interrupted by Kevin Z who takes over smoothly and talks about eyes and sex in lizardfishes posted at Deep Sea News. Kevin now with a square pass to John Wilkins who ponders a rather big question in our understanding of speciation: how many concepts of species are out there? He passes the ball all the way to Hannah Waters in the 16 meter box, who cleanly intercepts the ball while asking a related question: are Eukarya actually part of the Archaea domain, making life a two-domain system, or does the three-domain system still hold? But just as she is about to turn the ball around preparing for a shot at the goal, the referee (whom some say is biased towards the now-defunct 5 domain hypothesis) whistles for an offside violation, prompting loud boos from the crowd! Hannah grudgingly relinquishes the ball, which is given to the other team.

Evolution and Creationism

ProbabilityZero dead-balls a strong and furious kick. Furious over the agenda of the US Tea Party that includes teaching creationism in US public schools. All this in the recurial blog. The ball travels to Jayson D Cooke who is asking in an open letter why the University of Southern Queensland in Australia is hosting a creationist event under a scientific guise, he also defended his opinion on the air. Meanwhile in the stands, Michael D. Barton is selling cartoons of Darwin and evolution (from both sides of the fence, also here) from The Dispersal of Darwin. Some of the football fans accuse Michael of selling products of a man who advocated “Might is Right”. That is patently untrue, for many different reasons, the chief one being a misunderstanding of the word “fittest” in “survival of the fittest”. Fittest does not means “strongest”, but “the best able to reproduce”. However, Michael’s business associate, Eric Johnson decides to talk to the crowd about Darwin as a compassionate person, as manifested in his opposition to vivisection.

Lucas Brouwers from thoughtomics appears from ProbabilityZero’s blind-side, grabs the ball and, considerably faster than plate tectonics, advances up the pitch to the rival penalty box. Although, speaking of plate tectonics, Lucas talks about how freshwater crabs help us map continental drift. He is tackled by a rival player, falls, gets up, picking burrs from his socks, and wondering how they evolved? (The burrs, not the socks.) The answer comes from Melissa who while out walking the dog talks about the burry man, the burry dog and burdock. Why she is walking the dog in the middle of a football game? No idea.

Lucas forward-passes to another player concerned with speciation, Jeremy Yoder at Denim and Tweed talks about the speciation of rockfish: it appears that in many cases depth, not geographic distance, is the allopatric factor in rockfish speciation.  He passes it to DeLene Beeland who takes this question even further: how do we define species in the first place? She turns the ball around, sets for a kick and… goooooaaaaaaal!!!!! Yes! In the stands, Digital Cuttlefish dances with joy.

The referee whistles for halftime, and the players, sweaty and covered with mud and burrs step off the pitch.

Halftime

While we are waiting for the second half to begin, Bjørn Østman tells the viewers at home why intelligent people watch more TV. Or, perhaps not? Read to find out. This public service announcement has been sponsored by Time Tree: just enter the names two species, and find out how long ago they diverged! While the players are resting, they audience watches a beautiful video of the Applied Evolution Summit in Heron Island, courtesy of R. Ford Denison from This Week in Evolution. Also, Bjørn announces the long-awaited results of the Carnival of Evolution Readers Survey. One interesting point that came up is the contentious phrasing of the question: “do you believe in evolution?”

The second half begins. A short pass by Greg Laden explaining what is the most important human adaptation. (Hint: no, not bipedalism.) Zen Faulkes sprints forward – and wonders: did sprinting behavior shape the stings of scorpions, or is this explanation yet another “just so” evolutionary story? Cross-pass to R. Ford Denison who talks about the evolutionary benefits of cooperation and kin selection. Specifically, that Hamilton’s rule still holds, even though it has recently come under fire in a much publicized article in Nature. Competition is also an adaptive force, and Becky Ward tells us about the weird competition between a spider and a plant: both of which are predators! She passes to Lucas Brouwers, who makes small adjustment to the ball’s trajectory before passing it on, noting that evolution also generates novelty through subtle tinkering.

So how does the game end? It doesn’t. Evolution does not end. It just keeps going on and on and on… The next Carnival will be hosted at This Scientific Life. It is never to early to submit.

You can still contribute. So if you are a blogger with a post on evolution, go to the blog carnival site to submit. (Please do not email me.) Submissions will be accepted until October 30. The 29th edition will be posted here November 1.

Of course, I never do anything without researching it first, because I am such an awesome scientist, or detail-oriented !@#*^, depending on whether you ask me or my students. So I looked up “substance” in the Merriam-Webster dictionary. Here is what I found:

Main Entry: sub·stance
Pronunciation: \ˈsəb-stən(t)s\
Function: noun
Etymology: Middle English, from Anglo-French, from Latin substantia, from substant-, substans, present participle of substare to stand under, from sub- + stare to stand — more at stand
Date: 14th century

1 a : essential nature : essence b : a fundamental or characteristic part or quality c Christian Science : god 1b
2 a : ultimate reality that underlies all outward manifestations and change b : practical importance : meaning, usefulness
3 a : physical material from which something is made or which has discrete existence b : matter of particular or definite chemical constitution c : something (as drugs or alcoholic beverages) deemed harmful and usually subject to legal restriction

4 : material possessions : property

Hmmm… 2a and 2b seem to be relevant. Perhaps 3c should be too, as my blogging could be construed harmful to other more productive activities, which I am obviously not engaged with at this moment. Actually you, gentle reader,  are not engaged in more productive activities either right now. Be that as it may, the word substance does seem to have an air of permanence about it, which is contrary to the perceived ephemeral nature of blogging. Bora is actually one of the people who are doing something about making blogs less ephemeral by publishing The Open Laboratory collection (full disclosure: I’m published in the 2009 book) and by supporting science bloggers, blogging and activities wherever they may be. This makes me so happy to be among Bora’s chosen 10 (OK, 11, he cheated a bit) among the hundreds of blogs he must be reading. Thanks Bora!

I do wonder though, eighty-five years from now, how many of us science bloggers would be remembered for our blogging? Well, maybe not as individuals, but what kind of impact are we having now, and how much will it remain 85 years from now? Hopefully as a collective, science bloggers are impacting the understanding of science, which is one of the reasons I am blogging. Hopefully, we do have substance, as a group if not as individuals.

Why eighty-five years? Well, the answer to that brings me to the main topic  (substance?) part of this post, which is the  anniversary of the Scopes trial. This month, 85 years ago, a schoolteacher in Tennessee was convicted of a high misdemeanor for violating the State of Tennessee’s Butler Act which prohibited the teaching of evolution in any of the state’s public schools and universities. He was fined $100.

PUBLIC ACTS

OF THE

STATE OF TENNESSEE

PASSED BY THE

SIXTY – FOURTH GENERAL ASSEMBLY

1925

________

CHAPTER NO. 27

House Bill No. 185

(By Mr. Butler)

AN ACT prohibiting the teaching of the Evolution Theory in all the Universities, Normals and all other public schools of Tennessee, which are supported in whole or in part by the public school funds of the State, and to provide penalties for the violations thereof.

Section 1. Be it enacted by the General Assembly of the State of Tennessee, That it shall be unlawful for any teacher in any of the Universities, Normals and all other public schools of the State which are supported in whole or in part by the public school funds of the State, to teach any theory that denies the story of the Divine Creation of man as taught in the Bible, and to teach instead that man has descended from a lower order of animals.

Section 2. Be it further enacted, That any teacher found guilty of the violation of this Act, Shall be guilty of a misdemeanor and upon conviction, shall be fined not less than One Hundred $ (100.00) Dollars nor more than Five Hundred ($ 500.00) Dollars for each offense.

Section 3. Be it further enacted, That this Act take effect from and after its passage, the public welfare requiring it.

Passed March 13, 1925

W. F. Barry,

Speaker of the House of Representatives

L. D. Hill,

Speaker of the Senate

Approved March 21, 1925.

Austin Peay,

Governor.

Seems incredible at this day an age… or maybe not so incredible given recent events in Louisiana.

William Jennings Bryan, counsel for the prosecution, attacking evolution

The city of Dayton as the organ grinder profiting from the Scopes trial

The trial, which originated as something of a publicity affair for the town of Dayton, Tennessee, quickly became a battleground for evolution vs. creation. In the short term, the trial actually increased the number of anti-evolution bills proposed in different state legislatures in the US. In the long term, however, Tennessee vs. Scopes is seen as a watershed moment in the teaching and public acceptance of evolution, and has had long terms ramifications in the US and internationally. Scopes himself  spoke only once at the trial, was not called to testify, and only had this to say when granted a statement after sentence was passed:

Your honor, I feel that I have been convicted of violating an unjust statute. I will continue in the future, as I have in the past, to oppose this law in any way I can. Any other action would be in violation of my ideal of academic freedom — that is, to teach the truth as guaranteed in our constitution, of personal and religious freedom. I think the fine is unjust.

Now that is substance.

Back to the award;  I still have some conditions to fulfill:

1. Sum up your blogging motivation, philosophy and experience in exactly 10 words.

¹Blogging ²motivation, ³philosophy ⁴and ⁵experience ⁶cannot ⁷be ⁸summed ⁹in ¹⁰ten ¹¹words.

2. Pass this award on to 10 other blogs

Given the 10ⁿ growth rate of tagged blogs, chain-letter fashion, I wonder about how this Blogging with Substance award has originated. Search engines was no help, as so many blogs are now tagged with the Blogging with Substance. If someone has an answer, let me know. Anyhow, here are my 10 tags, based on what I am reading nowadays, ephemerality of blogging substance, and all that jazz. Tough choices though, so many good blogs out there:

1. Blue Collar Bioinformatics

2. Sandwalk

3. Thoughtomics

4. The Loom

5. Mike the Mad Biologist

6. Genomics, Evolution and Pseudoscience

7. Circle of Complexity

8. Buried Treasure

9. The Tree of Life

10. Mystery Rays form Outer Space

Final word: if this post seems a bit confused, and you are not sure that you are “getting it”, well, that’s this post’s substance.