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Software

Challenges with Data Quality, Sharing, and Versioning in Next-Generation Sequencing

An fine talk by David Dooling highlighting  some of the false impressions about second generation sequencing. A partial list: Why sequencing quality trump base pair output Why genomes are really probabilities rather than strings Why centralized repositories break down when it comes to second generation sequencing data. Collaborative Software development and versioning has been moving [...]

Ada Lovelace Day 2009. Women in Technology: Hypatia of Alexandria

Hypatia  (b. ~360CE  d. 415CE) was a mathematician, philosopher, astronomer and teacher in Roman Alexandria. She was also quite probably the last librarian of the famous Library of Alexandria. Note that at the time, the definition of Philosophy was much broader, and encompassed what we term today the natural and exact sciences; and yes, she [...]

On Molecular Viewers, or why I voted for RasMol

Beware the temptation to use the 45 and 120 degree angle pink and yellow light source, in combination with shiny plastic B-splines, which would make your protein model look like brothel decor

Happy Birthday Linux

March 14 is also the anniversary of the release of Linux kernel 1.0, with all of its 176,250 lines of code. The current 2.6.28 has  crossed the 10,000,000 threshold. Tux should have a birthday Pi…. but here is some other Tux confectionery:

Not dead, overloaded

When the Moon is in the Seventh House, and Jupiter aligns with Mars, a bunch of people gather for their “Bioinformaticians anonymous” group therapy. There they metaphorically gather, commiserating about how bioinformatics is dead (or was it bioinformaticians?), just smells funny or suffers from identity theft, probably because it got drunk at the last ISMB, [...]

Ten years of coding with the snake

Biopython is entering its 10th year; the unofficial birthday is on September, since that is when the mailing list started: September 1999. I stumbled onto that list mid-September, 1999. I believe the Python version was 1.5, I was still working on SGI Irix, and I was an 0.3 PhD candidate. Today I am coding with [...]