Comments on: Freeloading pays off, but only up to a point. http://bytesizebio.net/index.php/2009/08/25/freeloading-pays-off-but-only-up-to-a-point/ The musings and ravings of a computational biologist about science, computers, music and, you know, stuff Sat, 05 May 2012 18:13:49 +0000 hourly 1 http://wordpress.org/?v=3.3.2 By: farful http://bytesizebio.net/index.php/2009/08/25/freeloading-pays-off-but-only-up-to-a-point/comment-page-1/#comment-556 farful Tue, 08 Sep 2009 15:43:33 +0000 http://bytesizebio.net/?p=2208#comment-556 This article reminded me of this: http://www.nature.com/nature/journal/v446/n7136/full/446616a.html This article reminded me of this:
http://www.nature.com/nature/journal/v446/n7136/full/446616a.html

]]> By: leonardo http://bytesizebio.net/index.php/2009/08/25/freeloading-pays-off-but-only-up-to-a-point/comment-page-1/#comment-545 leonardo Sun, 30 Aug 2009 20:56:43 +0000 http://bytesizebio.net/?p=2208#comment-545 Is their (small) software available? Is their (small) software available?

]]> By: Iddo http://bytesizebio.net/index.php/2009/08/25/freeloading-pays-off-but-only-up-to-a-point/comment-page-1/#comment-544 Iddo Fri, 28 Aug 2009 20:11:53 +0000 http://bytesizebio.net/?p=2208#comment-544 <a href="#comment-543" rel="nofollow">@Ian Holmes</a> Good point. Diggle et al managed to derive metabolic costs using two types of mutants. I guess that C & H wanted to explore the theoretic possibilities of all types of possible mutants within the 3-loci space, and to establish a proof of principle for this model. They did look only at "cheap" and "expensive" costs, and did not explore that space more continuously. They did show that it is sensible. Now we need someone to drum up a few mutants in addition to those of Diggle et. al Also, I don't think anyone has actually found cheating mutants in nature. Diggle has shown experimentally that these mutants can survive and thrive, and C&H and others have show that it is likely they exist... but I don't think a cheating strain of QS-bacteria has been isolated yet. Correct me if I am wrong. @Ian Holmes
Good point. Diggle et al managed to derive metabolic costs using two types of mutants. I guess that C & H wanted to explore the theoretic possibilities of all types of possible mutants within the 3-loci space, and to establish a proof of principle for this model. They did look only at “cheap” and “expensive” costs, and did not explore that space more continuously. They did show that it is sensible. Now we need someone to drum up a few mutants in addition to those of Diggle et. al

Also, I don’t think anyone has actually found cheating mutants in nature. Diggle has shown experimentally that these mutants can survive and thrive, and C&H and others have show that it is likely they exist… but I don’t think a cheating strain of QS-bacteria has been isolated yet. Correct me if I am wrong.

]]> By: Ian Holmes http://bytesizebio.net/index.php/2009/08/25/freeloading-pays-off-but-only-up-to-a-point/comment-page-1/#comment-543 Ian Holmes Fri, 28 Aug 2009 19:09:39 +0000 http://bytesizebio.net/?p=2208#comment-543 for comparison, here is a cellular automaton simulation that's tied to empirical data: http://www.nature.com/nature/journal/v413/n6858/full/413841a0.html for comparison, here is a cellular automaton simulation that’s tied to empirical data:
http://www.nature.com/nature/journal/v413/n6858/full/413841a0.html

]]> By: Ian Holmes http://bytesizebio.net/index.php/2009/08/25/freeloading-pays-off-but-only-up-to-a-point/comment-page-1/#comment-542 Ian Holmes Fri, 28 Aug 2009 19:00:54 +0000 http://bytesizebio.net/?p=2208#comment-542 The Czárán & Hoekstra cellular automaton simulation is fun, but doesn't anyone get a little worried by the fact that their metabolic costs are basically dreamed up out of thin air? It's not like they've exhaustively explored the parameter space. The Czárán & Hoekstra cellular automaton simulation is fun, but doesn’t anyone get a little worried by the fact that their metabolic costs are basically dreamed up out of thin air? It’s not like they’ve exhaustively explored the parameter space.

]]> By: Alejandro Montenegro-Montero http://bytesizebio.net/index.php/2009/08/25/freeloading-pays-off-but-only-up-to-a-point/comment-page-1/#comment-541 Alejandro Montenegro-Montero Thu, 27 Aug 2009 14:41:04 +0000 http://bytesizebio.net/?p=2208#comment-541 Hi Iddo. This is a very interesting post. I selected it as one of my "picks of the week" of posts aggregated at RB in molecular biology, over at my blog http://amontenegro.blogspot.com/2009/08/bacterial-freeloaders-early-metastasis.html Cheers, -A Hi Iddo.

This is a very interesting post.
I selected it as one of my “picks of the week” of posts aggregated at RB in molecular biology, over at my blog http://amontenegro.blogspot.com/2009/08/bacterial-freeloaders-early-metastasis.html
Cheers,
-A

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